Key result
H-FABP testing demonstrated higher sensitivity (92.65%) compared to CK-MB (54.41%) and troponin (61.76%) for the early detection of myocardial infarction within 6 hours of chest pain onset.
Why the study?
Does H-FABP improve early detection of acute myocardial infarction compared to troponin and CK-MB in patients presenting with chest pain within 6 hours of onset?
Observational (n=200)
Does H-FABP improve early detection of acute myocardial infarction compared to troponin and CK-MB in patients presenting with chest pain within 6 hours of onset?
Absolute Event Rate: 92.65% vs 61.76%
H-FABP offers higher sensitivity but lower specificity than troponin and CK-MB for detecting myocardial infarction within 6 hours of chest pain onset, suggesting it may be a useful adjunctive early biomarker.
May support earlier MI detection; hypothesis-generating and requires prospective validation before clinical adoption.
Background Heart-type fatty acid binding protein has been proposed as an early biomarker of myocardial infarction. However, the usefulness of this test is still debatable.Aims We compared H-FABP with troponin and CK-MB in the early detection of acute myocardial infarction in patients presenting with chest pain with regard to sensitivity, specificity and time of detection.Methods Blood samples for H-FABP, troponin and CK-MB were obtained from 200 patients presenting with chest pain within the first 6 hours from its onset with suspicious acute coronary syndromes. Serial measurement of troponin and CK-MB were performed. Sensitivity and specificity of the cardiac markers were calculated.Results Our study showed better sensitivity of H-FABP than CK-MB and troponin (92.65% vs 54.41% and 61.76%), respectively. It showed also a specificity of 75.00%, 87.50% and 93.75% for FABP, CK-MB and troponin, respectively.Conclusion Qualitative H-FABP test showed a higher sensitivity than CK-MB and cTnI in the early detection of myocardial infarction. However, the combination with troponin is necessary to confirm the diagnosis or exclusion of acute myocardial infarction.
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Hamza et al. (2016) conducted an observational in Acute coronary syndromes (n=200). Heart-type fatty acid-binding protein (H-FABP) vs. Troponin and CK-MB was evaluated on Sensitivity for early detection of acute myocardial infarction. H-FABP testing demonstrated higher sensitivity (92.65%) compared to CK-MB (54.41%) and troponin (61.76%) for the early detection of myocardial infarction within 6 hours of chest pain onset.
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