Key result
H-FABP demonstrated a sensitivity of 89.7% and specificity of 68% for the early diagnosis of AMI, superior to initial cTnI (62.1%) and CK-MB (44.8%).
Why the study?
Does H-FABP determination improve the early diagnosis of acute myocardial infarction in patients presenting with acute chest pain compared to cTnI and CK-MB?
Population
54 patients presenting with acute ischemic chest pain at the emergency department
Comparison
H-FABP determination at admission using… vs Serial cardiac troponin I and creatinine…
Design
Cohort
Authors
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H-FABP may aid early AMI detection in chest pain; hypothesis-generating and should not change practice without prospective validation.
Observational (n=54)
Does H-FABP determination improve the early diagnosis of acute myocardial infarction in patients presenting with acute chest pain compared to cTnI and CK-MB?
Absolute Event Rate: 89.7% vs 62.1%
H-FABP is a highly sensitive early biomarker for acute myocardial infarction, particularly within the first 6 hours of symptom onset, outperforming initial cTnI and CK-MB.
Vupputuri et al. (2015) conducted an observational in Acute chest pain (n=54). H-FABP determination vs. cTnI and CK-MB was evaluated on Sensitivity for diagnosis of AMI. H-FABP demonstrated a sensitivity of 89.7% and specificity of 68% for the early diagnosis of AMI, superior to initial cTnI (62.1%) and CK-MB (44.8%).