Key result
Human heart-type fatty acid-binding protein (h-FABP) testing yielded a sensitivity of 69% (95% CI 59-77) and specificity of 74% (95% CI 66-80) for early diagnosis of AMI.
Why the study?
Does h-FABP point-of-care testing improve the early diagnosis of acute myocardial infarction in patients presenting to the emergency department with chest pain or dyspnoea?
Population
280 consecutive patients presenting to the emergency department with chest pain or dyspnoea within 24 h of…
Comparison
Human heart-type fatty acid-binding protein… vs Standard diagnostic work-up, including repeated…
Design
Cohort
Authors
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Too low for stand-alone AMI rule-out in the ED; leaves open adjunctive biomarker strategies for prospective validation.
Observational (n=280)
Does h-FABP point-of-care testing improve the early diagnosis of acute myocardial infarction in patients presenting to the emergency department with chest pain or dyspnoea?
Effect estimate: Sensitivity 69% (95% CI 59-77)
While h-FABP detects myocardial damage earlier than troponin T, its sensitivity (69%) and specificity (74%) are too low for it to serve as a stand-alone rule-out test for AMI.
Mad et al. (2007) conducted an observational in acute myocardial infarction (n=280). human heart-type fatty acid-binding protein (h-FABP) vs. standard diagnostic work-up (ECG and troponin T) was evaluated on Sensitivity for early diagnosis of AMI (Sensitivity 69%, 95% CI 59-77). Human heart-type fatty acid-binding protein (h-FABP) testing yielded a sensitivity of 69% (95% CI 59-77) and specificity of 74% (95% CI 66-80) for early diagnosis of AMI.
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