Heart-type fatty acid-binding protein in the early diagnosis of acute myocardial infarction: a systematic review and meta-analysis
Key result
Heart-type fatty acid-binding protein (H-FABP) yielded a pooled sensitivity of 84% (95% CI 76-90%) and specificity of 84% (95% CI 76-89%) for the early diagnosis of acute myocardial infarction.
Why the study?
Does H-FABP testing accurately diagnose acute myocardial infarction in patients suspected of having AMI?
Population
16 studies pooling 3709 consecutive patients suspected of having acute myocardial infarction, median age…
Comparison
Heart-type fatty acid-binding protein testing vs Reference standard for AMI
Design
Meta-analysis
Authors
Discussion
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Implication
H-FABP lacks sufficient accuracy for standalone early AMI diagnosis; reinforces troponin-based strategies while leaving combined use unresolved.
Study Design
Type
Meta-Analysis (n=3,709)
Structured PICO
Does H-FABP testing accurately diagnose acute myocardial infarction in patients suspected of having AMI?
P
Population
3,709 consecutive patients suspected of having acute myocardial infarction across 16 studies.
E
Exposure
Heart-type fatty acid-binding protein (H-FABP) testing
C
Comparator
Reference standard for AMI (troponin, creatine kinase, or creatine kinase-myocardial band)
O
Outcome
Sensitivity and specificity for the early diagnosis of AMIsurrogate
Main Result
Effect estimate: Sensitivity 84%, Specificity 84% (95% CI 76-90 for sensitivity; 76-89 for specificity)
H-FABP does not have sufficient sensitivity or specificity to be used as a stand-alone test for the early diagnosis of acute myocardial infarction.
Cite This Study
Slot et al. (2010) conducted a meta-analysis in acute myocardial infarction (n=3,709). Heart-type fatty acid-binding protein (H-FABP) was evaluated on Sensitivity and specificity for early diagnosis of AMI (Sensitivity 84%, Specificity 84%, 95% CI 76-90 for sensitivity; 76-89 for specificity). Heart-type fatty acid-binding protein (H-FABP) yielded a pooled sensitivity of 84% (95% CI 76-90%) and specificity of 84% (95% CI 76-89%) for the early diagnosis of acute myocardial infarction.