Key result
Novel 2-amino-1,4-dihydropyridine derivatives show prolonged antihypertensive action in hypertensive rats.
Why the study?
Novel 2-amino-1,4-dihydropyridine derivatives with nitroxy-alkoxycarbonyl groups were synthesized to evaluate their antihypertensive effects and structure-activity relationships.
Do novel 2-amino-1,4-dihydropyridine derivatives improve antihypertensive activity in spontaneously hypertensive rats?
Do novel 2-amino-1,4-dihydropyridine derivatives improve antihypertensive activity in spontaneously hypertensive rats?
A novel structure-activity modification in 2-amino-1,4-dihydropyridine derivatives with a tertiary amino group yields prolonged antihypertensive effects in a hypertensive rat model.
Novel 2-amino-1,4-dihydropyridine derivatives, which contain nitroxy-alkoxycarbonyl groups at the 3- and/or 5-position, were synthesized and their pharmaceutical effect was evaluated in spontaneously hypertensive rats. The structure-activity relationships are discussed in terms of potency, onset-rapidity, and duration of antihypertensive activity. Remarkably prolonged duration of antihypertensive action was observed when a tertiary amino group was introduced on either side of an ester chain.
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Kobayashi et al. (1995) studied Hypertension. Novel 2-amino-1,4-dihydropyridine derivatives was evaluated on Antihypertensive activity (potency, onset-rapidity, and duration). Novel 2-amino-1,4-dihydropyridine derivatives with a tertiary amino group demonstrated a remarkably prolonged duration of antihypertensive action in spontaneously hypertensive rats.
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