Key result
Prolonging prophylactic antibiotics beyond 24 hours showed no significant difference in surgical site infection rates among 207 patients undergoing clean elective orthopaedic surgery.
Why the study?
Does prolonging prophylactic antibiotics beyond 24 hours reduce the rate of surgical site infection in clean elective orthopaedic surgeries?
Population
207 patients undergoing clean elective orthopaedic surgery
Comparison
Intravenous prophylactic antibiotics for 48… vs Intravenous prophylactic antibiotics for 24 hours
Design
RCT, Randomized
Follow-up
3 months
Authors
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Supports limiting prophylactic antibiotics to 24 hours in clean elective orthopaedic surgery; confirms no benefit from prolongation in this RCT.
RCT (n=207)
randomized
Does prolonging prophylactic antibiotics beyond 24 hours reduce the rate of surgical site infection in clean elective orthopaedic surgeries?
Prolonging prophylactic antibiotics beyond 24 hours provides no additional benefit in preventing surgical site infections in clean elective orthopaedic surgeries.
Shrestha et al. (2013) conducted an RCT in clean elective orthopaedic surgeries (n=207). Prophylactic antibiotics for 24 hours vs. Prophylactic antibiotics for 48 hours or 48 hours IV plus 7 days oral was evaluated on surgical site infection. Prolonging prophylactic antibiotics beyond 24 hours showed no significant difference in surgical site infection rates among 207 patients undergoing clean elective orthopaedic surgery.
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