Key result
Prolonging preoperative prophylactic antibiotics beyond 24 hours did not significantly reduce the rate of surgical site infection in patients undergoing clean elective orthopaedic surgery.
Why the study?
Does prolonging prophylactic antibiotics beyond 24 hours reduce surgical site infection in clean elective orthopaedic surgeries?
Population
207 patients undergoing clean elective orthopaedic surgery in Nepal. Excluded patients with earlier wounds…
Comparison
Intravenous prophylactic antibiotics for 24… vs Intravenous prophylactic antibiotics for 48…
Design
RCT, Randomized into 3 groups using random numbers generated by software…
Follow-up
3 months
Authors
Loading...
Supports limiting prophylaxis to 24 hours; reinforces guidelines against routine prolongation in clean elective orthopaedic surgery.
RCT (n=207)
Randomized
Does prolonging prophylactic antibiotics beyond 24 hours reduce surgical site infection in clean elective orthopaedic surgeries?
Prolonging preoperative prophylactic antibiotics beyond 24 hours does not provide additional benefit in reducing surgical site infections in clean elective orthopaedic surgeries.
Shrestha et al. (2013) conducted an RCT in Clean elective orthopaedic surgery (n=207). Prolonged prophylactic antibiotics (48 hours IV or 48 hours IV plus 7 days oral) vs. 24 hours IV prophylactic antibiotics was evaluated on Surgical site infection. Prolonging preoperative prophylactic antibiotics beyond 24 hours did not significantly reduce the rate of surgical site infection in patients undergoing clean elective orthopaedic surgery.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: