February 1, 1988AJP Endocrinology and Metabolism

Angiotensin II causes a dual effect on potassium permeability in adrenal glomerulosa cells

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Population

Bovine adrenal glomerulosa cells

Comparison

Angiotensin II vs Control conditions

Design

Preclinical

Authors

MLMaría V. LoboUniversity of Chile EMElisa T. MarusicUniversidad de Santiago de Chile

Discussion

Member takes

Implication

Hypothesis-generating for adrenal K+ channel modulation; leaves open translation to human aldosterone disorders or therapy.

Structured PICO

Population

Bovine adrenal glomerulosa cells

Intervention

Angiotensin II

Comparator

Control conditions (absence of angiotensin II, presence of apamin/tetraethylammonium, or altered calcium concentrations)

Outcome

86Rb release/efflux (as a measure of potassium permeability)surrogate

Angiotensin II modulates membrane potential in bovine adrenal glomerulosa cells through a biphasic, calcium-dependent effect on potassium permeability.

Cite This Study

Lobo et al. (1988) studied this question.

synapsesocial.com/papers/6a86e64436c36f97809ec204 https://doi.org/10.1152/ajpendo.1988.254.2.e144

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Angiotensin II causes a dual effect on potassium permeability in adrenal glomerulosa cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II causes a dual effect on potassium permeability in adrenal glomerulosa cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider