Key result
Elastin insufficiency in mice led to significantly elevated right ventricular systolic pressures and structural remodeling of proximal pulmonary arteries compared to wild-type controls.
Why the study?
Does elastin insufficiency increase pulmonary circulatory pressures and alter elastic artery structure in mice?
Population
3-month-old male and female transgenic and knockout mice in the C57BL/6 background with graded vascular…
Comparison
Elastin insufficiency vs Wild-type controls and hBAC-mWT
Design
Preclinical, An observer blinded to genotype performed all analyses.
Authors
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No immediate clinical implications; leaves open whether elastin pathways contribute to human pulmonary hypertension.
Does elastin insufficiency increase pulmonary circulatory pressures and alter elastic artery structure in mice?
Absolute Event Rate: 77.9% vs 19.8%
p-value: p=<0.0001
Elastin insufficiency in mice leads to elevated pulmonary pressures and altered pulmonary artery structure without extensive pathological cardiac remodeling, suggesting a developmental adaptation to maintain right-sided cardiac output.
Shifren et al. (2008) studied Elastin insufficiency and pulmonary hypertension. Elastin insufficiency vs. Wild-type mice was evaluated on Right ventricular systolic pressure (p=<0.0001). Elastin insufficiency in mice led to significantly elevated right ventricular systolic pressures and structural remodeling of proximal pulmonary arteries compared to wild-type controls.
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