Key result
An abnormal ISTH-BAT score was associated with significantly higher prothrombin consumption compared to a normal score (14% vs 8%, p=0.006) in patients with mild platelet function disorders.
Why the study?
Bleeding risk in patients with mild platelet function disorders is difficult to assess and their phenotype remains ill-explored.
Is prothrombin consumption associated with a hemorrhagic phenotype in patients with mild platelet function disorders?
Observational (n=20)
Is prothrombin consumption associated with a hemorrhagic phenotype in patients with mild platelet function disorders?
Prothrombin consumption may serve as a useful laboratory indicator of bleeding risk in patients with mild platelet function disorders.
May refine phenotyping of mild platelet disorders; leaves open which labs predict bleeding risk.
BACKGROUND: The bleeding risk of patients with mild platelet function disorders is difficult to assess and their phenotype remains ill-explored. AIM: This study was designed to establish a comprehensive biological phenotype of patients with mild platelet function disorders. METHODS: Twenty patients were included with persistent abnormal light transmission aggregometry (LTA). The ISTH bleeding assessment tool (ISTH-BAT) was assessed to identify laboratory analyses associated with an abnormal hemorrhagic score. RESULTS: The majority of patients had defects that might affect Gαi protein signaling pathways or minor abnormalities. No LTA nor flow cytometry parameters were associated with an above-normal hemorrhagic score. However, prothrombin consumption, which corresponds to the ratio of serum residual factor II to plasma residual factor II, was significantly higher (p = .006) in the abnormal ISTH-BAT group (mean = 14%, SD = 6) compared with the normal ISTH-BAT group (mean = 8%, SD 4). Prothrombin consumption was significantly associated with ISTH-BAT score (r = .5287, IC 95% 0.0986-0.7924, p = .0165). CONCLUSION: In this group of patients, there was an association between a pathological bleeding score and increased prothrombin consumption. This test could be used as an additional indicator of platelet function abnormality liable to be related to bleeding risk.
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Babuty et al. (2023) conducted an observational in mild platelet function disorders (n=20). Abnormal ISTH-BAT score vs. Normal ISTH-BAT score was evaluated on Prothrombin consumption (r = 0.5287, 95% CI 0.0986-0.7924, p=0.006). An abnormal ISTH-BAT score was associated with significantly higher prothrombin consumption compared to a normal score (14% vs 8%, p=0.006) in patients with mild platelet function disorders.
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