Why the study?
Does autonomic blockade with propranolol or atropine reveal differences in heart rate response to exercise between native Tibetan and acclimatized Han residents of high altitude?
Population
19 acclimatized male residents of Lhasa, Tibet Autonomous Region, China, comprising 10 native Tibetans and 9…
Comparison
Beta-sympathetic blockade or parasympathetic… vs Placebo administered during the same exercise…
Design
RCT, random order on different days
Authors
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Autonomic differences may influence exercise responses in high-altitude migrants; extends mechanistic understanding of native Tibetan adaptation.
Does autonomic blockade with propranolol or atropine reveal differences in heart rate response to exercise between native Tibetan and acclimatized Han residents of high altitude?
Native Tibetan residents of high altitude exhibit more parasympathetic and less beta-sympathetic tone during exercise compared to acclimatized Han newcomers, though this does not fully explain their greater exercise capacity.
Zhuang et al. (1993) studied this question.
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