November 20, 2012Arthritis Care & Research
Association of systemic lupus erythematosus with angiographically defined coronary artery disease: A retrospective cohort study
Key result
After adjustment for known risk factors, systemic lupus erythematosus was associated with a significantly increased likelihood of obstructive coronary artery disease (OR 2.24; 95% CI 1.08-4.67).
Why the study?
Is systemic lupus erythematosus associated with a higher prevalence of obstructive coronary artery disease in patients undergoing coronary angiography?
Population
344 patients undergoing cardiac catheterization for the evaluation of CAD, including 86 with systemic lupus…
Comparison
Systemic lupus erythematosus (SLE) vs Non-SLE controls matched by sex and year of…
Design
Cohort
Follow-up
median 4.3 years
Authors
Discussion
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Implication
May warrant CAD vigilance in SLE despite younger age; leaves open need for prospective validation and targeted strategies.
Study Design
Type
Cohort (n=344)
Structured PICO
Is systemic lupus erythematosus associated with a higher prevalence of obstructive coronary artery disease in patients undergoing coronary angiography?
P
Population
344 patients (85% women) undergoing cardiac catheterization for CAD evaluation, including 86 with SLE and 258 sex- and year-matched controls, followed for a median of 4.3 years.
E
Exposure
Systemic lupus erythematosus (SLE)
C
Comparator
Non-SLE controls matched by sex and year of cardiac catheterization
O
Outcome
Obstructive CAD, defined as ≥70% stenosis in a major epicardial coronary arterysurrogate
Main Result
Odds Ratio: 2.24 (95% CI 1.08–4.67)
Absolute Event Rate: 52% vs 62%
Systemic lupus erythematosus is associated with a more than twofold increased odds of obstructive coronary artery disease, despite these patients being significantly younger and having fewer traditional metabolic risk factors.
Limitations
- Selected population (patients already undergoing cardiac catheterization)
Cite This Study
Kaul et al. (2012) conducted a cohort in Systemic lupus erythematosus (SLE) (n=344). Systemic lupus erythematosus vs. Non-SLE controls was evaluated on Obstructive CAD (≥70% stenosis in a major epicardial coronary artery) (OR 2.24, 95% CI 1.08-4.67). After adjustment for known risk factors, systemic lupus erythematosus was associated with a significantly increased likelihood of obstructive coronary artery disease (OR 2.24; 95% CI 1.08-4.67).