Key result
An antimicrobial stewardship intervention significantly improved correct indication, correct dose, and overall compliance for surgical antibiotic prophylaxis (P < 5.6·1012 for overall compliance).
Why the study?
Appropriate surgical antibiotic prophylaxis reduces surgical site infections, but inappropriate application causes emerging infections and antibiotic resistance, prompting the evaluation of an antimicrobial stewardship intervention.
Does an Antimicrobial Stewardship intervention improve the appropriateness of Surgical Antibiotic Prophylaxis in elective surgical cases?
Population
2059 elective surgical cases in phase 1 and 1781 in phase 2 across 12 surgical units in an Italian hospital
Comparison
Phase 2 (post-audit) vs Phase 1 (pre-audit)
Design
Prospective study organized in three subsequent phases
Authors
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Stewardship may boost prophylaxis compliance; leaves open effects on infections or resistance.
Observational (n=3,840)
No
Does an Antimicrobial Stewardship intervention improve the appropriateness of Surgical Antibiotic Prophylaxis in elective surgical cases?
p-value: p=< 5.6·1012
An antimicrobial stewardship intervention involving guidelines, workflow optimization, and audits significantly improved the appropriateness of surgical antibiotic prophylaxis.
Tiri et al. (2020) conducted an observational in Surgical Antibiotic Prophylaxis (SAP) appropriateness (n=3,840). Antimicrobial Stewardship (AMS) intervention vs. Pre-intervention phase (Phase 1) was evaluated on Overall compliance with surgical antibiotic prophylaxis (p=< 5.6·1012). An antimicrobial stewardship intervention significantly improved correct indication, correct dose, and overall compliance for surgical antibiotic prophylaxis (P < 5.6·1012 for overall compliance).
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