Key result
Endothelial COX-1 may contribute to vascular dysfunction, challenging the traditional view that it is solely a protective, constitutive isoform.
Design
Review
Authors
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Questions endothelial COX-1 protective role; leaves open whether isoform-selective targeting alters vascular outcomes.
The review highlights the evolving understanding of COX isoforms, suggesting that endothelial COX-1 may contribute to vascular dysfunction rather than being purely protective.
PM Vanhoutte (2009) conducted a review in Vascular dysfunction. Endothelial COX-1 was evaluated. Endothelial COX-1 may contribute to vascular dysfunction, challenging the traditional view that it is solely a protective, constitutive isoform.
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