Predictors of normotension on withdrawal of antihypertensive drugs in elderly patients: prospective study in second Australian national blood pressure study cohort
Key result
Younger age (65-74 years), lower on-treatment systolic blood pressure, single agent treatment, and greater waist:hip ratio predicted maintenance of normotension 12 months after drug withdrawal.
Population
503 patients aged 65-84 with treated hypertension who were withdrawn from all antihypertensive drugs and…
Design
Cohort
Follow-up
12 months
Authors
Discussion
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Member takes
Implication
May guide selection for deprescribing trials; leaves open whether withdrawal is safe in routine care.
Study Design
Type
Cohort (n=503)
Multicenter
Yes
Structured PICO
P
Population
503 patients aged 65-84 with treated hypertension who were withdrawn from antihypertensive drugs and remained normotensive for two weeks, followed for 12 months.
E
Exposure
Withdrawal of all antihypertensive drugs
O
Outcome
Relative likelihood of maintaining normotension 12 months after drug withdrawal; relative likelihood of early return to hypertension after drug withdrawalsurrogate
Age, baseline blood pressure control, and the number of antihypertensive drugs are key predictors of maintaining normotension after drug withdrawal in elderly patients.
Cite This Study
Mark Nelson (2002) conducted a cohort in Hypertension (n=503). Withdrawal of antihypertensive drugs was evaluated on Relative likelihood of maintaining normotension 12 months after drug withdrawal. Younger age (65-74 years), lower on-treatment systolic blood pressure, single agent treatment, and greater waist:hip ratio predicted maintenance of normotension 12 months after drug withdrawal.