In vitro and in silico studies of the interaction between glucocorticoid drug mometasone furoate and model lung surfactant monolayer

This is the authors' abstract. We don't add key points for this paper.

study. The failure of the drug to permeate into the lipid bilayer is most likely what causes this collapse. On the other hand, for inhalation breathing, the monolayer forms pores induced by the high drug concentrations. Our investigation also reveals that mometasone furoate exhibits different spreading behaviors because of their affinities to the surfactant molecules. This work may have implications for the use of inhaled steroids in the treatment of asthma in addition to its translational significance in the management of chronic lung disease.