Key result
Pravastatin significantly reduced heart rate, left ventricular Tei index, and systolic pulmonary arterial pressure, and increased stroke volume compared to control in dogs with mitral regurgitation.
Why the study?
Does pravastatin improve cardiac function in dogs with mitral regurgitation?
RCT (n=14)
Randomly divided
No
Does pravastatin improve cardiac function in dogs with mitral regurgitation?
Adding pravastatin to standard therapy in dogs with mitral regurgitation improved echocardiographic parameters of cardiac function and pulmonary hypertension.
Answers are grounded in this paper and cite their sources.
May support statin evaluation in canine mitral regurgitation; hypothesis-generating and should not yet change practice.
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Arita et al. (2014) conducted an RCT in Mitral regurgitation (n=14). Pravastatin vs. Control (generic therapy without pravastatin) was evaluated on Heart rate, left ventricular Tei index, systolic pulmonary arterial pressure, and stroke volume. Pravastatin significantly reduced heart rate, left ventricular Tei index, and systolic pulmonary arterial pressure, and increased stroke volume compared to control in dogs with mitral regurgitation.
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