Key result
Pravastatin administration at 2.0 mg/kg for 4 weeks in healthy dogs significantly reduced cardiac output (0.65 L/min vs 0.86 L/min) and left atrial pressure indices compared to unmedicated controls.
Why the study?
Does pravastatin alter echocardiographic and hemodynamic parameters in healthy dogs?
RCT (n=5)
Randomly assigned crossover
No
Does pravastatin alter echocardiographic and hemodynamic parameters in healthy dogs?
In healthy dogs, pravastatin increases left ventricular expansion capacity and decreases left ventricular constriction and left atrial pressure, suggesting potential utility for treating canine heart failure with diastolic dysfunction.
Answers are grounded in this paper and cite their sources.
Should not change canine practice; hypothesis-generating for pravastatin in diastolic dysfunction, requiring disease-model validation.
The purpose of this study was to determine the effect of pravastatin (PS) on hemodynamic parameters in healthy dogs. Five beagle dogs were repeatedly used in each of the 4 groups. One group was not medicated (control). Dogs in other groups received 0.5, 1.0 or 2.0 mg/kg PS orally q24hr, for 4 weeks. Physical examination, blood biochemical tests, blood pressure measurements and Doppler echocardiography were performed before and 1, 2 and 4 weeks after PS administration in all dogs. PS significantly reduced the left atrial-to-aortic diameter ratio (LA/Ao), early diastolic transmitral flow (E) wave, E/early diastolic mitral annulus motion velocity (Em) ratio, left ventricular (LV) fractional shortening, LV ejection fraction, mid systolic myocardial velocity gradient, stroke volume (SV), cardiac output (CO), right and left ventricular Tei indices and elevated Em and early diastolic myocardial velocity gradient. Heart rate was not significantly altered during PS administration, but mean blood pressure decreased slightly. The hematological and blood biochemical values were within normal limits during PS administration. These results revealed that PS administration increases LV expansion capacity and decreases LV constriction and left atrial pressure. It has been suggested that PS may be effective in improving heart failures with LV diastolic dysfunction or elevated left atrial pressure in dogs.
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Arita et al. (2013) conducted an RCT in Healthy (n=5). Pravastatin vs. No medication (control) was evaluated on Cardiac output at 4 weeks (2.0 mg/kg dose) (p=<0.05). Pravastatin administration at 2.0 mg/kg for 4 weeks in healthy dogs significantly reduced cardiac output (0.65 L/min vs 0.86 L/min) and left atrial pressure indices compared to unmedicated controls.
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