Key result
Administration of dobutamine, esmolol, milrinone, or phenylephrine to healthy dogs resulted in fairly stable left atrial phasic function indices that did not parallel changes in LV function indices.
Why the study?
Do cardiovascular drugs (dobutamine, esmolol, milrinone, phenylephrine) alter left atrial phasic function indices in healthy dogs?
Do cardiovascular drugs (dobutamine, esmolol, milrinone, phenylephrine) alter left atrial phasic function indices in healthy dogs?
Left atrial phasic function indices measured by 2D speckle tracking echocardiography remain relatively stable despite drug-induced changes in left ventricular function in healthy dogs.
LA phasic indices appear resilient to these agents in healthy dogs; leaves open applicability in disease models or clinical translation.
OBJECTIVE: To evaluate the effects of dobutamine, esmolol, milrinone, and phenylephrine on left atrial phasic function of healthy dogs. ANIMALS: 9 healthy Beagles. PROCEDURES: Following sedation with propofol on each of 4 experimental days, dogs were administered a constant rate infusion of dobutamine (5 μg/kg/min), esmolol (500 μg/kg/min), milrinone (25 μg/kg, IV bolus, followed by 0.5 μg/kg/min), or phenylephrine (2 μg/kg/min). There was at least a 14-day interval between experimental days. Each drug was administered to 6 dogs. Conventional and 2-D speckle tracking echocardiography were performed before (baseline) and after administration of the cardiovascular drug, and time-left atrial area curves were derived to calculate indices for left atrial reservoir, conduit, and booster pump functions (left atrial phasic function) and left ventricular contractility and lusitropy. RESULTS: Compared with baseline values, indices for left atrial reservoir and booster pump functions and left ventricular contractility and lusitropy were significantly increased following dobutamine administration; indices for left atrial phasic function and left ventricular lusitropy were changed insignificantly, and indices for left ventricular contractility were significantly impaired following esmolol administration; indices for left atrial phasic function and left ventricular relaxation were changed insignificantly, and indices for left ventricular systolic function were significantly augmented following milrinone administration; and indices for left atrial phasic function and left ventricular lusitropy were changed insignificantly, and indices of ventricular contractility were significantly impaired following phenylephrine administration. CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that, following administration of dobutamine, esmolol, milrinone, or phenylephrine to healthy dogs, left atrial phasic function indices were fairly stable and did not parallel changes in left ventricular function indices.
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Osuga et al. (2015) studied healthy dogs (n=9). dobutamine, esmolol, milrinone, and phenylephrine vs. baseline was evaluated on indices for left atrial reservoir, conduit, and booster pump functions and left ventricular contractility and lusitropy. Administration of dobutamine, esmolol, milrinone, or phenylephrine to healthy dogs resulted in fairly stable left atrial phasic function indices that did not parallel changes in LV function indices.
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