Key result
2D strain parameters accurately identified subclinical impairment of left ventricular function earlier than other echocardiographic indices in an animal model of acute heart failure.
Why the study?
Do 2D strain parameters detect subclinical impairment of left ventricular function earlier than traditional echocardiographic indices in an animal model of acute heart failure?
Do 2D strain parameters detect subclinical impairment of left ventricular function earlier than traditional echocardiographic indices in an animal model of acute heart failure?
In an animal model of acute heart failure, 2D strain parameters identified subclinical left ventricular dysfunction earlier than traditional echocardiographic indices such as LVEF, E/e', and the Tei index.
Answers are grounded in this paper and cite their sources.
Supports 2D strain for earlier LV impairment detection in acute HF models; leaves open human validation before clinical adoption.
INTRODUCTION: Numerous newer parameters have been established for sensitive and reproducible evaluation of left ventricular (LV) dysfunction. We assessed the performance of these parameters in sequential monitoring of LV function in an animal model of controllable drug-induced LV dysfunction. METHODS: To establish predictable aggravating LV dysfunction, seven male beagle dogs were anesthetized and received intermittent injection of esmolol and propofol of gradually increasing dosage. Parameters reflecting LV function were measured after each drug infusion. These included LV ejection fraction (LVEF) measured by both two-dimensional (2D) and three-dimensional (3D) echocardiography, Tei index, ratio of early diastolic transmitral flow velocity to early diastolic mitral annular velocity (E/e') and 2D strain-derived parameters. Changes in these parameters over time were compared with the baseline value. RESULTS: Changes in 2D and 3D LVEF were observed after infusion with propofol (5 mg/kg) and esmolol (3.5 mg/kg). Doppler-derived parameters including E/e' and the Tei index failed to detect LV dysfunction prior to 2D LVEF. Significant changes in 2D strains and strain rates (SRs) could be induced by relatively small anesthetic dosages (∼4 mg propofol/kg and 2.5 mg esmolol/kg). Strain-derived parameters were generally highly reproducible and longitudinal strain had the best intraobserver and interobserver reproducibility. CONCLUSIONS: The 2D strain parameters provide accurate identification of subclinical impairment of LV function earlier than all other echocardiographic indices.
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Li et al. (2010) studied Acute Heart Failure (Animal Model) (n=7). 2D strain parameters vs. 2D/3D LVEF, Tei index, E/e' was evaluated on Detection of left ventricular dysfunction. 2D strain parameters accurately identified subclinical impairment of left ventricular function earlier than other echocardiographic indices in an animal model of acute heart failure.
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