November 1, 1994Clinical and Experimental Pharmacology and Physiology

Sodium Loads Enhance the Natriuretic Responses to Atrial Natriuretic Peptide and Neutral Endopeptidase Inhibitors in Conscious Cynomolgus Monkeys

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Why the study?

Does sodium loading enhance the natriuretic response to ANP and NEP inhibitors in conscious monkeys?

Population

Conscious cynomolgus monkeys

Comparison

Sodium loading with human atrial natriuretic… vs Normal sodium diet (0.55% sodium) or vehicle

Design

Preclinical

Authors

ASAndrea A. SeymourMerck & Co., Inc., Rahway, NJ, USA (United States)MAMagdi M. AsaadBristol-Myers Squibb (Germany)BABenoni E. Abboa‐OffeiBristol-Myers Squibb (United States)

Discussion

Member takes

Implication

Hypothesis-generating in primates; should not yet inform human cardiorenal therapy with NEP inhibitors.

Structured PICO

Does sodium loading enhance the natriuretic response to ANP and NEP inhibitors in conscious monkeys?

Population

Conscious cynomolgus monkeys

Intervention

Sodium loading (dietary 1.1% sodium, 25 mEq oral load, or IV saline) with human atrial natriuretic peptide (hANP 99-126) and/or neutral endopeptidase inhibitors (SQ 28,603 or candoxatrilat)

Comparator

Normal sodium diet (0.55% sodium) or vehicle

Outcome

Natriuretic response (sodium excretion)surrogate

Sodium loading enhances the natriuretic activity of hANP and NEP inhibitors in conscious monkeys, mediated partly by increased ANP delivery to distal renal tubules.

Cite This Study

Seymour et al. (1994) studied this question.

synapsesocial.com/papers/6a86f25cd08104c969cb9b03 https://doi.org/10.1111/j.1440-1681.1994.tb02455.x

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Sodium Loads Enhance the Natriuretic Responses to Atrial Natriuretic Peptide and Neutral Endopeptidase Inhibitors in Conscious Cynomolgus Monkeys

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Sodium Loads Enhance the Natriuretic Responses to Atrial Natriuretic Peptide and Neutral Endopeptidase Inhibitors in Conscious Cynomolgus Monkeys

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider