Key result
Systemic sclerosis was associated with impaired right atrial reservoir strain (49.3% vs 59.6%, p=0.000) and increased right atrial stiffness compared with healthy subjects.
Cross-Sectional (n=95)
Absolute Event Rate: 49.3% vs 59.6%
p-value: p=0.000
In patients with systemic sclerosis, right atrial mechanics are impaired and increased RA stiffness is an independent predictor of reduced functional capacity.
May flag subclinical right heart involvement in systemic sclerosis; extends speckle-tracking data to RA stiffness and functional capacity.
Cardiac involvement in systemic sclerosis (SSc) implies a worse prognosis. Little is known about the right atrial (RA) mechanics in this disease, but recent data suggest that it correlates well with the functional capacity of the patients in conditions with known right heart involvement. Thus we aimed to investigate the abnormalities of the RA function as compared with healthy subjects and to assess the potential correlations between RA mechanics and the functional capacity in SSc patients using 2D speckle tracking technique. A total of 70 SSc patients (age: 57 ± 12 years) were investigated. Functional capacity was measured with 6-minute walk test (6MWT). Echocardiographic parameters of the right ventricular (RV) systolic function (TAPSE, RVFAC), parameters of the tricuspid inflow (E, A), and tricuspid annular systolic (S), early- (e') and late- (a') diastolic myocardial velocities were measured. RV wall thickness was obtained. RA reservoir (ε R ), conduit (ε CD ), and contractile (ε CT ) strain were measured. RA stiffness was calculated as ratio of E/e' to ε R . Echocardiographic data were compared with an age- and gender-matched group of 25 healthy volunteers. RA ε R (49.3 ± 10.7 vs 59.6 ± 9.9%, p = 0.000) and ε CD (26.8 ± 8.1 vs 34.3 ± 7.3%, p = 0.000) were significantly lower in SSc patients. No significant difference was found in ε CT (22.9 ± 5.8 vs 25.3 ± 5.7%, p = 0.082). RA stiffness was significantly increased in SSc patients (0.11 ± 0.04 vs 0.08 ± 0.02, p = 0.001). 6MWT distance was 391 ± 95m. In stepwise multiple linear regression analysis RV wall thickness (r = − 0.289, p = 0.030) and RA stiffness (r = − 0.418, p = 0.002) became independent predictors of 6MWT distance. In conclusion, RA ε R and ε CD are impaired, while RA stiffness is increased in SSc compared with healthy subjects. Speckle tracking-derived RA stiffness is turned out to be one of the main determinants of the functional capacity in SSc patients.
No takes yet. Share an insight, caveat, or question.
Nógrádi et al. (2018) conducted a cross-sectional in Systemic sclerosis (n=95). Systemic sclerosis vs. Healthy volunteers was evaluated on Right atrial reservoir strain (ε R) (p=0.000). Systemic sclerosis was associated with impaired right atrial reservoir strain (49.3% vs 59.6%, p=0.000) and increased right atrial stiffness compared with healthy subjects.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: