Population
Platelet/red blood cell suspensions perfused through a 1.3-mm-ID tube onto collagen-coated glass
Design
Preclinical
Authors
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ADP may predominate in shear-dependent platelet activation; hypothesis-generating for targeted inhibition pending in vivo validation.
In an in vitro model of platelet accumulation, only ADP is released in sufficient local concentrations to independently affect platelet aggregation.
Adams et al. (1983) studied this question.
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