Key result
The SHARPEN score demonstrated limited discriminative ability (AUC-ROC 0.66) for predicting in-hospital mortality in patients with infective endocarditis undergoing cardiac surgery, showing no significant difference compared to other existing scores.
Why the study?
The SHARPEN score predicts in-hospital mortality in patients hospitalized for infective endocarditis, but its performance compared with other available surgical scores has not yet been carried out.
Does the SHARPEN score accurately predict in-hospital mortality in patients with infective endocarditis undergoing cardiac surgery compared to other risk scores?
Cohort (n=101)
No
Does the SHARPEN score accurately predict in-hospital mortality in patients with infective endocarditis undergoing cardiac surgery compared to other risk scores?
The SHARPEN score has limited applicability in clinical practice for predicting in-hospital mortality in patients undergoing cardiac surgery for infective endocarditis, performing similarly to other existing scores with only moderate accuracy.
Answers are grounded in this paper and cite their sources.
SHARPEN score shows modest discrimination in surgical IE; leaves open whether it outperforms other scores for risk stratification.
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Lech et al. (2023) conducted a cohort in Infective endocarditis undergoing cardiac surgery (n=101). SHARPEN score vs. Other surgical scores (EuroSCORE, EuroSCORE II, STS-IE, PALSUSE, AEPEI, EndoSCORE, RISK-E) was evaluated on In-hospital mortality prediction (discriminative ability) (AUC-ROC 0.66, 95% CI 0.54-0.79, p=0.008). The SHARPEN score demonstrated limited discriminative ability (AUC-ROC 0.66) for predicting in-hospital mortality in patients with infective endocarditis undergoing cardiac surgery, showing no significant difference compared to other existing scores.
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