Why the study?
Does alteplase improve angiographic changes and clinical outcomes in patients with refractory unstable angina undergoing subsequent angioplasty?
Population
36 patients with refractory unstable angina at rest despite bedrest and medical treatment including heparin…
Comparison
Alteplase 100 mg infused over 3 hours prior to… vs Matching placebo infused over 3 hours prior to…
Design
RCT, randomized, double-blind, placebo-controlled
Follow-up
within 24 hours
Authors
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Alteplase before angioplasty in refractory unstable angina increases bleeding without angiographic benefit; challenges routine pre-procedural use and reinforces medical management.
Does alteplase improve angiographic changes and clinical outcomes in patients with refractory unstable angina undergoing subsequent angioplasty?
In patients with refractory unstable angina, alteplase prior to angioplasty does not improve angiographic or clinical outcomes and increases bleeding risk.
Brand et al. (1991) studied this question.
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