Key result
Histamine inhibits KCNQ/M currents in HEK293 cells and rat superior cervical ganglion neurons via phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis mediated by H1 receptor and PLC stimulation.
Authors
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No immediate clinical implications; leaves open histamine-H1 effects on KCNQ channels in cardiovascular models.
Liu et al. (2008) studied this question. Histamine was evaluated on KCNQ2/Q3 current inhibition. Histamine inhibits KCNQ/M currents in HEK293 cells and rat superior cervical ganglion neurons via phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis mediated by H1 receptor and PLC stimulation.
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