Key result
Histamine induces an inward current in cultured human aortic endothelial cells carried mainly by Cl-, which may provide a constant driving force for sustained Ca2+ entry.
In cultured human aortic endothelial cells, histamine induces a chloride current that provides a constant driving force for sustained calcium entry.
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No immediate clinical impact; leaves open whether this Cl- current sustains endothelial Ca2+ signaling in vivo.
Ono et al. (1998) studied this question. Histamine vs. Absence of histamine was evaluated on Whole-cell currents and intracellular Ca2+ concentration. Histamine induces an inward current in cultured human aortic endothelial cells carried mainly by Cl-, which may provide a constant driving force for sustained Ca2+ entry.
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