Key result
The structural unit that controls the excitation-contraction coupling signal in skeletal muscle appears to be the alpha1S/beta1a pair of the dihydropyridine receptor.
Population
Cultured myotube models lacking specific dihydropyridine receptor subunits and ryanodine receptor type 1…
Design
Review
Authors
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Does not support clinical practice changes in muscle disorders; leaves open targeted validation in disease models.
This review highlights that the alpha1S/beta1a pair of the skeletal dihydropyridine receptor is the essential structural unit controlling excitation-contraction coupling signaling in skeletal muscle.
Coronado et al. (2004) conducted a review in Excitation-contraction coupling in skeletal muscle. The structural unit that controls the excitation-contraction coupling signal in skeletal muscle appears to be the alpha1S/beta1a pair of the dihydropyridine receptor.
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