Population
Dyspedic myotubes
Comparison
Expression of RyR1-RyR3 chimerae vs Wild-type RyR1 and RyR3
Design
Preclinical
Authors
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No immediate clinical implications for muscle disorders; extends RyR1-DHPR domain mapping while leaving open full in vivo rescue requirements.
The structural and functional link between RyR1 and skeletal muscle DHPR requires multiple interacting regions, with the D2 domain of RyR1 playing a key role in stabilizing this interaction.
Sheridan et al. (2006) studied this question.
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