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January 1, 1979Brain

Necrosis of muscle cells is initiated by loss of plasma membrane, followed by Z disc lysis and mitochondrial changes, with empty basal lamina tubes indicating failed regeneration.

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Population

30 boys with Duchenne muscular dystrophy

Design

Case_series

Authors

SCStirling CarpenterGKGeorge Karpati

Discussion

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Overview

Plasma membrane stabilization may warrant exploration in DMD; case report leaves generalizability and therapeutic impact open.

Structured PICO

P
Population
30 boys with Duchenne muscular dystrophy
O
Outcome
Pathological sequence of muscle cell necrosis and regenerationsurrogate

Muscle cell necrosis in Duchenne muscular dystrophy appears to be initiated by plasma membrane loss, which can sometimes be repaired if the defect is small.

Cite This Study

Carpenter et al. (1979) studied this question.

synapsesocial.com/papers/6a86f8a5bb0787ff27ca13a8https://doi.org/10.1093/brain/102.1.147
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Blood vessel structure in Duchenne muscular dystrophy. I. Light and electron microscopic observations in resting muscle1977 · 20 citations
  2. 2Muscle fiber degeneration and necrosis in muscular dystrophy and other muscle diseases: Cytochemical and immunocytochemical data1984 · 51 citations
  3. 3Apoptosis precedes necrosis of dystrophin-deficient muscle1995 · 237 citations
  4. 4Pathogenesis of Duchenne muscular dystrophy: The calcium hypothesis revisited1992 · 10 citations
  5. 5Lifespan Analysis of Dystrophic mdx Fast-Twitch Muscle Morphology and Its Impact on Contractile Function2021 · 16 citations