Key result
Acidic pH increased the frequency of bursting in KcsA channels without affecting intraburst dwell times, while voltage modulated burst frequency and properties.
A kinetic model describes the gating events in KcsA, showing that protons promote activation while voltage modulates pathways connecting open and inactivated states.
No takes yet. Share an insight, caveat, or question.
Hypothesis-generating for pH-voltage gating in bacterial channels; leaves open translation to human cardiac potassium channels.
Chakrapani et al. (2007) studied KcsA channel gating. Acidic pH and voltage was evaluated on Kinetic transitions and single-channel currents. Acidic pH increased the frequency of bursting in KcsA channels without affecting intraburst dwell times, while voltage modulated burst frequency and properties.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: