Key result
Primary aldosteronism is relatively common in newly diagnosed diabetic patients with hypertension and is associated with higher blood pressure compared to those without primary aldosteronism.
Why the study?
To investigate the prevalence of primary aldosteronism in newly diagnosed diabetic patients with hypertension, compare clinical differences between essential hypertension and primary aldosteronism, and explore associations with plasma aldosterone concentration.
What is the prevalence of primary aldosteronism in newly diagnosed diabetic patients with hypertension?
Observational (n=270)
What is the prevalence of primary aldosteronism in newly diagnosed diabetic patients with hypertension?
p-value: p=<0.01
Primary aldosteronism is relatively common in newly diagnosed diabetic patients with hypertension, suggesting a need for active aldosterone screening in those with grade 2 or higher hypertension.
OBJECTIVES: To investigate the prevalence of primary aldosteronism (PA) in newly diagnosed diabetic patients with hypertension and to compare clinical differences between newly diagnosed diabetes mellitus with essential hypertension (EH) and PA, and to explore the relationship between plasm aldosterone concentration (PAC) and clinical biochemical variables. METHODS: A total of 270 newly diagnosed diabetic patients with hypertension were prospectively enrolled in this study. All patients were screened for PA. The positive patients in the screening test were further confirmed by captopril challenge test (CCT) to determine the prevalence of PA. Clinical biochemical indexes were detected. RESULTS: <0.01, respectively). CONCLUSIONS: The prevalence of PA is relatively high in newly diagnosed diabetic patients with hypertension. Patients with hypertension above grade 2 should be actively screened for aldosterone. Newly diagnosed diabetic patients with hypertension combined with PA has a higher hypertension compared with the patients without PA.In newly diagnosed diabetic patients with hypertension, PAC may be related to insulin resistance.
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Hu et al. (2020) conducted an observational in Newly diagnosed diabetes mellitus with hypertension (n=270). Primary aldosteronism vs. Essential hypertension without primary aldosteronism was evaluated on Prevalence of primary aldosteronism and clinical differences (p=<0.01). Primary aldosteronism is relatively common in newly diagnosed diabetic patients with hypertension and is associated with higher blood pressure compared to those without primary aldosteronism.
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