Why the study?
Does kindling-induced epilepsy alter the properties of NMDA receptor channels in dentate gyrus granule cells in rats?
Population
Dentate gyrus granule cells acutely isolated from control and epileptic (kindled) rats
Comparison
Kindling-induced epilepsy vs Control rats
Design
Preclinical
Authors
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May sustain kindling in rat models; leaves open translation to human epilepsy and targeted therapies.
Does kindling-induced epilepsy alter the properties of NMDA receptor channels in dentate gyrus granule cells in rats?
Kindling-induced epilepsy causes lasting functional modifications in single NMDA receptor channels, including increased open times and decreased Mg2+ block, which may underlie the maintenance of the epileptic state.
Köhr et al. (1993) studied this question.
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