What question did this study set out to answer?

To determine sequential changes in sympatho-neuronal regulation and cardiac contractile performance following volume overload induced by aortic regurgitation.

October 2, 1993European Heart Journal

Sequential changes in sympatho-neuronal regulation and contractile function following aortic regurgitation in rabbit heart

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Why the study?

Does volume overload from aortic regurgitation alter sympatho-neuronal regulation and contractile function in a rabbit model?

Population

40 rabbits

Comparison

Aortic regurgitation produced by perforation of… vs Sham operation

Design

Preclinical, Randomly assigned to a 1-day group, a 1-week group, and a 4-week…

Follow-up

Up to 4 weeks

Authors

TYTsutomu YoshikawaHeart Failure & Transplant THTakashi HandaHiroshima University TYTatsuya YamadaTokyo University of Science

Discussion

Member takes

Implication

Transient beta-adrenoceptor changes in rabbit volume overload are hypothesis-generating; leaves open translation to human aortic regurgitation pathophysiology and therapy.

Key Points

To determine sequential changes in sympatho-neuronal regulation and cardiac contractile performance following volume overload induced by aortic regurgitation.
Randomly assigned 40 rabbits to aortic regurgitation (aortic valve perforation, n=20) or sham operation (n=20) across 1-day, 1-week, and 4-week observation periods.
Assessed hemodynamics, left ventricular wall thickness, plasma and myocardial norepinephrine concentrations, and myocardial beta-adrenoceptor binding sites using 125I-iodocyanopindolol.
Left ventricular end-diastolic pressure increased and cardiac output decreased progressively during the first week post-procedure, followed by normalization toward baseline levels and increased left ventricular free wall thickness at 4 weeks.
Plasma norepinephrine rose at 1 day, while myocardial beta-adrenoceptor maximal binding capacity and myocardial norepinephrine significantly decreased at 1 day and 1 week before restoring fully by 4 weeks.

Structured PICO

Does volume overload from aortic regurgitation alter sympatho-neuronal regulation and contractile function in a rabbit model?

Population

40 rabbits

Intervention

Aortic regurgitation produced by perforation of the aortic valve

Comparator

Sham operation

Outcome

Sequential changes in haemodynamics, myocardial beta-adrenoceptor binding number, and catecholamines at 1 day, 1 week, and 4 weekssurrogate

In a rabbit model of aortic regurgitation, early volume overload causes transient decreases in myocardial beta-adrenoceptors and norepinephrine that restore as compensatory hypertrophy develops.

Cite This Study

Yoshikawa et al. (1993) studied this question.

synapsesocial.com/papers/6a86fcf4ddd5671cb07cc545 https://doi.org/10.1093/eurheartj/14.10.1404

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Implication

Transient beta-adrenoceptor changes in rabbit volume overload are hypothesis-generating; leaves open translation to human aortic regurgitation pathophysiology and therapy.

Sequential changes in sympatho-neuronal regulation and contractile function following aortic regurgitation in rabbit heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Sequential changes in sympatho-neuronal regulation and contractile function following aortic regurgitation in rabbit heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

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