What question did this study set out to answer?

To compare the quorum sensing inhibitory activity of synthetic alkyl-DPD analogues directly against a natural fimbrolide commonly considered the benchmark inhibitor.

October 13, 2009Journal of the American Chemical Society

Revisiting AI-2 Quorum Sensing Inhibitors: Direct Comparison of Alkyl-DPD Analogues and a Natural Product Fimbrolide

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Authors

CLColin A. LoweryUniversity of Richmond TATakumi AbeOkayama University JPJunguk ParkSamsung (South Korea)

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Implication

Comparative in vitro study reveals superior quorum sensing inhibition by alkyl-DPD analogues over fimbrolide in bacteria, challenging the natural product's gold standard status.

Key Points

To compare the quorum sensing inhibitory activity of synthetic alkyl-DPD analogues directly against a natural fimbrolide commonly considered the benchmark inhibitor.
Completed a revised chemical synthesis of a standard fimbrolide natural product.
Conducted head-to-head inhibitory assays comparing the fimbrolide against a panel of alkyl-DPD analogues in Vibrio harveyi and Salmonella typhimurium.
Alkyl-DPD analogues exhibited greater potency than the fimbrolide in inhibiting AI-2-mediated quorum sensing across both Vibrio harveyi and Salmonella typhimurium.
The comparative data challenge the conventional designation of fimbrolide-derived compounds as the gold standard for AI-2 quorum sensing inhibition.

Cite This Study

Lowery et al. (2009) studied this question.

synapsesocial.com/papers/6a86ff7ecbde9db34bcb92d4 https://doi.org/10.1021/ja9066783

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Implication

Comparative in vitro study reveals superior quorum sensing inhibition by alkyl-DPD analogues over fimbrolide in bacteria, challenging the natural product's gold standard status.

Revisiting AI-2 Quorum Sensing Inhibitors: Direct Comparison of Alkyl-DPD Analogues and a Natural Product Fimbrolide

Discussion

Member takes

Implication

Key Points

Cite This Study

Revisiting AI-2 Quorum Sensing Inhibitors: Direct Comparison of Alkyl-DPD Analogues and a Natural Product Fimbrolide

Discussion

Member takes

Implication

Key Points

Cite This Study

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