Population
Inside-out membrane patches of Xenopus laevis oocytes expressing wild type and point mutants of a MaxiK…
Comparison
Point mutations in the S4 region of the hSlo… vs Wild type (WT) hSlo channel
Design
Preclinical
Authors
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Pinpoints key BK channel voltage-sensing residues; leaves open therapeutic translation pending human validation.
The S4 region in the hSlo channel is part of the voltage sensor, with Arg-210 and Arg-213 being the only charged residues contributing to the gating valence.
Díaz et al. (1998) studied this question.
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