Key result
The expression level of platelet GPIa/IIa among Taiwan Chinese varies over sixfold and significantly correlates with the GPIa gene 807 C/T dimorphisms (P<0.001).
Cross-Sectional (n=29)
No
p-value: p=<0.001
Platelet GPIa/IIa expression varies over sixfold in Taiwan Chinese and strongly correlates with GPIa gene 807 C/T polymorphisms, providing a genetic marker for predicting platelet receptor density and potential thrombotic risk.
GPIa 807 C/T may mark receptor density variation; leaves open prospective validation of thrombotic risk in Taiwan Chinese.
Glycoprotein (GP) Ia/IIa plays a key role in platelet function by acting as a primary receptor for subendothelial collagen, thereby contributing to arterial thrombosis. In this study, we found that the expression level of platelet GPIa/IIa among Taiwan Chinese varies over sixfold and this difference relates either to the GPIa gene 807 C/T dimorphisms or the appearance of BglII restriction sequence within intron G. This is the first study to demonstrate the wide variation of platelet GPIa/IIa density in an Oriental population and its correlation to the GPIa gene polymorphisms. These results provide useful tools for predicting platelet GPIa/IIa density of Chinese.
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Liu et al. (2006) conducted a cross-sectional in Healthy adults (n=29). GPIa gene 807 C/T dimorphisms vs. Between genotypes (807CC, 807CT, 807TT) was evaluated on Platelet GPIa/IIa density (fluorescence intensity) (p=<0.001). The expression level of platelet GPIa/IIa among Taiwan Chinese varies over sixfold and significantly correlates with the GPIa gene 807 C/T dimorphisms (P<0.001).
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