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August 5, 2003Blood

The contributions of the α2β1 integrin to vascular thrombosis in vivo

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Why the study?

Does alpha 2 beta 1 integrin deficiency prevent vascular thrombosis in vivo?

Population

alpha 2 beta 1 integrin-deficient mouse model

Design

Preclinical

Authors

LHLi HeLPLoretta PappanDGDavid G. Grenache

Discussion

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Overview

Alpha 2 beta 1 integrin may be a vessel-wall thrombosis target in animals; leaves open human therapeutic translation.

Structured PICO

Does alpha 2 beta 1 integrin deficiency prevent vascular thrombosis in vivo?

P
Population
alpha 2 beta 1 integrin-deficient mouse model
I
Intervention
alpha 2 beta 1 integrin deficiency
O
Outcome
Vascular thrombosis in 2 in vivo models (endothelial injury to the carotid artery and intravascular injection of collagen)surrogate

The alpha 2 beta 1 integrin is critically required for in vivo thrombus formation at the vessel wall under shear conditions following vascular injury.

Cite This Study

He et al. (2003) studied this question.

synapsesocial.com/papers/6a8d0d97b78e02efa68e4e76https://doi.org/10.1182/blood-2003-04-1323
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Integrin α2-Deficient Mice Develop Normally, Are Fertile, but Display Partially Defective Platelet Interaction with Collagen2002 · 268 citations
  2. 2Small-molecule inhibitors of integrin α 2 β 1 that prevent pathological thrombus formation via an allosteric mechanism2009 · 86 citations
  3. 3Mechanisms Involved in Platelet Vessel Wall Interaction1995 · 59 citations
  4. 4Reciprocal Signaling by Integrin and Nonintegrin Receptors during Collagen Activation of Platelets2003 · 97 citations
  5. 5Reduced thrombus stability in mice lacking the α2A-adrenergic receptor2006 · 67 citations