Population
Genetically obese Zucker rats, nonobese Zucker controls, and nonobese Zucker rats made obese by ventromedial…
Comparison
Genetic obesity or ventromedial hypothalamic… vs Nonobese Zucker controls
Design
Preclinical
Follow-up
up to 26 weeks
Authors
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Differentiates adipose expansion mechanisms in genetic versus hypothalamic rat obesity; leaves open relevance to human adiposity.
Genetic obesity in the Zucker rat is characterized by both adipocyte hypertrophy and hyperplasia, distinguishing it from obesity produced by hypothalamic lesioning which involves only hypertrophy.
Johnson et al. (1971) studied this question.
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