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Human monocyte-derived macrophages phagocytosed zymosan in the absence of serum opsonins. The capacity to ingest zymosan developed after the cells were cultured in vitro for 3 days and was inhibited completely by mannan. We conclude that human monocyte-derived macrophages phagocytose unopsonized zymosan predominantly via mannose receptors.
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Speert et al. (1985) studied this question.
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