Key result
In initially conservatively managed patients with severe aortic stenosis, diabetes mellitus was independently associated with a higher risk for a composite of aortic valve-related death or heart failure hospitalization (HR 1.33).
Why the study?
Does diabetes mellitus increase the risk of AV-related death or HF hospitalization in initially conservatively managed patients with severe aortic stenosis?
Cohort (n=2,618)
Yes
Does diabetes mellitus increase the risk of AV-related death or HF hospitalization in initially conservatively managed patients with severe aortic stenosis?
Hazard Ratio: 1.33 (95% CI 1.13–1.56)
Absolute Event Rate: 52.8% vs 42.9%
p-value: p=<0.001
In patients with severe aortic stenosis managed conservatively, the presence of diabetes mellitus significantly increases the long-term risk of aortic valve-related death or heart failure hospitalization.
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DM associated with higher composite AV death/HF hospitalization risk in conservative severe AS; leaves open need for targeted trials.
Song et al. (2020) conducted a cohort in Severe aortic stenosis (n=2,618). Diabetes mellitus vs. No diabetes mellitus was evaluated on Composite of aortic valve-related death and heart failure hospitalization (HR 1.33, 95% CI 1.13-1.56, p=<0.001). In initially conservatively managed patients with severe aortic stenosis, diabetes mellitus was independently associated with a higher risk for a composite of aortic valve-related death or heart failure hospitalization (HR 1.33).
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