Key result
New-generation bioresorbable scaffolds with thinner struts are being developed to overcome the higher adverse event rates seen with first-generation devices.
Why the study?
Randomized trials demonstrated higher rates of major adverse cardiac events and scaffold thrombosis with the first-generation Absorb compared to metallic everolimus-eluting stents, prompting the development of novel bioresorbable scaffold technologies.
New-generation bioresorbable scaffolds with thinner struts (<100 μm) and improved implantation techniques using intravascular imaging guidance are being developed to overcome the safety shortcomings of first-generation devices.
INTRODUCTION: The technology of bioresorbable scaffold (BRS) spread out after the success of the first-in-man trials of the Absorb. However, the randomized trials demonstrated that major adverse cardiac events and scaffold thrombosis rates of the first-generation Absorb were higher than those of the metallic everolimus-eluting stent. To overcome the shortcoming of the firstly commercialized Absorb, novel technologies have been developed. AREAS COVERED: In this review, we overviewed the field of BRS in the treatment of coronary, peripheral artery and gastrointestinal fields. To date, 10 BRS devices developed by 6 manufacturers have acquired the CE mark in coronary artery disease. Currently 8 BRS are in clinical trial phase, whereas 7 BRS are in preclinical assessment phase. Most new-generation devices have a strut thickness of less than 100 μm. However, late favorable outcome might be achieved not only by device refinement but also by a proper technique of implantation using intra vascular imaging guidance, as well as with a careful patient and lesion selection. EXPERT OPINION: New-generation BRS will be soon tested in the clinical arena to demonstrate improved acute and long-term of safety and efficacy.
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Kawashima et al. (2020) conducted a review in Cardiovascular disease, peripheral artery and gastrointestinal disease. Bioresorbable scaffolds (BRS) was evaluated. New-generation bioresorbable scaffolds with thinner struts are being developed to overcome the higher adverse event rates seen with first-generation devices.
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