Why the study?
Does intravenous diltiazem attenuate cardiovascular responses during tracheal extubation in ASA physical status I patients undergoing elective gynecologic surgery?
Population
80 ASA physical status I patients undergoing elective gynecologic surgery
Comparison
Intravenous diltiazem given 2 min before… vs Intravenous lidocaine or saline given 2 min…
Design
RCT, randomly assigned to one of four groups, double-blind
Follow-up
during and after tracheal extubation
Authors
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Supports pre-extubation diltiazem to blunt hemodynamic surges; confirms RCT efficacy versus control and extends lidocaine comparisons in elective surgery.
Does intravenous diltiazem attenuate cardiovascular responses during tracheal extubation in ASA physical status I patients undergoing elective gynecologic surgery?
Intravenous diltiazem given before tracheal extubation effectively attenuates the associated hemodynamic stress responses, with efficacy equal or superior to lidocaine.
Nishina et al. (1995) studied this question.
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