Key result
Continuous infusion of mouse APOA4 protein stimulated sympathetic activity in BAT and the liver, elevated BAT thermogenesis, and attenuated plasma and hepatic triglycerides and plasma insulin.
Why the study?
The physiological role of continuous infusion of recombinant APOA4 protein in regulating sympathetic activity, thermogenesis, and lipid and glucose metabolism in low-fat-diet-fed mice remained elusive.
Does continuous infusion of recombinant APOA4 protein improve sympathetic activity, thermogenesis, and lipid/glucose metabolism in low-fat-diet-fed male mice?
Population
Male mice fed a low-fat diet
Comparison
Continuous infusion of APOA4 protein vs saline treatment
Design
Preclinical animal study
Authors
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Continuous APOA4 infusion improves metabolism in obese mice; leaves open translation to human therapies.
Does continuous infusion of recombinant APOA4 protein improve sympathetic activity, thermogenesis, and lipid/glucose metabolism in low-fat-diet-fed male mice?
Continuous infusion of APOA4 protein in mice stimulates sympathetic activity and thermogenesis, improving lipid and glucose metabolism without affecting body weight.
Kuo et al. (2023) studied Low-fat-diet-fed male mice. Continuous infusion of mouse APOA4 protein vs. Saline was evaluated on Sympathetic activity, BAT temperature, energy expenditure, body weight, fat mass, caloric intake, glucose tolerance, and lipid levels. Continuous infusion of mouse APOA4 protein stimulated sympathetic activity in BAT and the liver, elevated BAT thermogenesis, and attenuated plasma and hepatic triglycerides and plasma insulin.
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