April 1, 1985Journal of Biological ChemistryOpen Access

Structural properties and lipid binding of human apolipoprotein A-IV.

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Population

Human apolipoprotein A-IV in dilute aqueous solution and model chylomicrons

Design

Preclinical

Authors

RWRichard B. WeinbergWake Forest University MSMona S. SpectorCold Spring Harbor Laboratory

Discussion

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Implication

Apo-A-IV lability cautions against fixed in vitro assumptions; leaves open its adaptive role in human lipid disorders.

Structured PICO

Population

Human apolipoprotein A-IV (apo-A-IV) in dilute aqueous solution and model chylomicrons (phospholipid-triglyceride emulsion)

Intervention

Environmental changes (pH alterations and guanidine hydrochloride denaturation)

Outcome

Structural characteristics (spectroscopic properties including fluorescence emission and circular dichroism) and lipid binding affinitysurrogate

Human apolipoprotein A-IV is marginally stable in aqueous solution, and its structural and lipid-binding properties are highly sensitive to environmental changes such as pH.

Cite This Study

Weinberg et al. (1985) studied this question.

synapsesocial.com/papers/6a87108c36c36f97809ed255 https://doi.org/10.1016/s0021-9258(18)89159-1

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Structural properties and lipid binding of human apolipoprotein A-IV.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Structural properties and lipid binding of human apolipoprotein A-IV.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider