Population
Recombinant human apolipoprotein A-V produced in E. coli, human apoA-V expressed in transgenic mice, and…
Comparison
In vitro structural and functional… vs Apolipoprotein A-I and unstimulated cells
Design
Preclinical
Authors
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ApoA-V's distinct structure and weak LCAT/efflux activity differentiate it from apoA-I; leaves open its precise role in human lipid disorders.
In vitro studies reveal that human apolipoprotein A-V has unique structural properties and does not significantly activate LCAT or promote cholesterol efflux, distinguishing its functional role in lipid homeostasis.
Beckstead et al. (2003) studied this question.
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