What question did this study set out to answer?

Synthesize structural, genetic, and cell biological discoveries regarding apolipoprotein A-V and its role in regulating plasma and intracellular triglyceride levels.

December 3, 2008Journal of Lipid ResearchOpen Access

The ins (cell) and outs (plasma) of apolipoprotein A-V

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TFTrudy M. ForteRutgers, The State University of New Jersey XSXiao ShuVanderbilt University RRRobert O. RyanUniversity of Nevada, Reno

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Implication

Extends ApoA-V mechanistic models in TG metabolism; leaves open therapeutic targeting in hypertriglyceridemia pending clinical studies.

Key Points

Synthesize structural, genetic, and cell biological discoveries regarding apolipoprotein A-V and its role in regulating plasma and intracellular triglyceride levels.
Evaluated findings from human genetic association studies linking apolipoprotein A-V single nucleotide polymorphisms to altered plasma triglyceride concentrations.
Analyzed biochemical characterizations of recombinant apolipoprotein A-V domains, receptor-binding elements, and cultured hepatoma cell trafficking assays.
Recombinant apolipoprotein A-V contains a lipid-binding C-terminal domain, an N-terminal helix bundle, and a positively charged motif (residues 185–228) that binds heparan sulfate proteoglycans and lipoprotein receptors.
Apolipoprotein A-V demonstrates poor secretion from cultured hepatoma cells, maintains very low circulating concentrations in plasma, and associates directly with cytosolic lipid droplets to modulate intracellular triglyceride metabolism.

Cite This Study

Forte et al. (2008) studied this question.

synapsesocial.com/papers/6a8244927db08d7cfd3f166b https://doi.org/10.1194/jlr.r800050-jlr200

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The ins (cell) and outs (plasma) of apolipoprotein A-V

Discussion

Member takes

Implication

Key Points

Cite This Study

The ins (cell) and outs (plasma) of apolipoprotein A-V

Discussion

Member takes

Implication

Key Points

Cite This Study

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