Why the study?
Does overexpression of human apolipoprotein A-V reduce plasma triglyceride concentration and alter lipoprotein distribution in genetically engineered mice?
Population
Genetically engineered mice (APOA5 Tg mice that overexpress the human apolipoprotein A-V gene and lack…
Comparison
Overexpression of human apolipoprotein A-V gene vs Mice deficient in apoA-V (apoa5(-/-) mice)
Design
Preclinical
Authors
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APOA5 modulates VLDL levels in mice; leaves open translation to human hypertriglyceridemia therapies.
Does overexpression of human apolipoprotein A-V reduce plasma triglyceride concentration and alter lipoprotein distribution in genetically engineered mice?
Overexpression of human apolipoprotein A-V in mice markedly reduces VLDL concentration and alters apolipoprotein ratios, highlighting its role in triglyceride homeostasis.
Nelbach et al. (2007) studied this question.
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