Key result
Cardiac resynchronization therapy in pediatric heart failure currently lacks prospective randomized controlled trials, with evidence limited to case reports and retrospective studies.
There is a significant gap in high-quality evidence and consensus guidelines regarding the use of cardiac resynchronization therapy in pediatric patients with heart failure and congenital heart disease.
CRT use in pediatric HF should remain cautious without RCTs; leaves open the need for prospective trials to inform guidelines.
Outcomes of Permanent CRT in Pediatric and CHDIn contrast to the adult CRT literature, there are currently no prospective, randomized, controlled trials evaluating CRT in pediatric HF, and there are no accepted consensus guidelines for implementation of CRT in the pediatric HF population.5,24 Information on the outcomes of pediatric CRT is limited to case reports and several retrospective single-center and multicenter studies with heterogeneous CHD populations (Table I in the online-only Data Supplement and Tables 1 and 2).
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Motonaga et al. (2014) conducted a review in Pediatric Heart Failure and Congenital Heart Disease. Cardiac Resynchronization Therapy was evaluated. Cardiac resynchronization therapy in pediatric heart failure currently lacks prospective randomized controlled trials, with evidence limited to case reports and retrospective studies.
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