Key result
Chronic right ventricular pacing in subjects with congenital complete AV block yielded an average 6-minute walk distance of 539.8 m, with female gender associated with lower HRQoL (P=0.009).
Why the study?
What are the determinants of health-related quality of life and functional capacity in children and young adults with congenital complete atrioventricular block undergoing chronic right ventricular pacing?
Observational (n=66)
What are the determinants of health-related quality of life and functional capacity in children and young adults with congenital complete atrioventricular block undergoing chronic right ventricular pacing?
In children and young adults with congenital complete AV block, chronic RV pacing does not severely impair HRQoL or physical capacity, though female gender, reduced LVEF, and cardiovascular drug use are associated with worse HRQoL.
Supports preserved capacity with chronic RV pacing in congenital AV block; leaves open gender-specific HRQoL influences for prospective study.
BACKGROUND: Although several studies have demonstrated deleterious consequences of chronic right ventricular (RV) pacing on ventricular function and synchronicity, its effects on health-related quality of life (HRQoL) and functional exercise capacity remain uncertain. We aimed to evaluate the effect of RV pacing on HRQoL and functional capacity of children and young adults with congenital complete atrioventricular block (CCAVB). METHODS: We included 66 consecutive subjects with RV cardiac pacemaker due to CCAVB and under clinical follow-up for more than 1 year. Multidimensional HRQoL scores were evaluated by Short Form-36 Health Survey (SF-36) and Child Health Questionnaire-Parent Form 50 (CHQ-PF50). Functional capacity was tested by a 6-minute walk distance test (6MWDT). Association analysis was performed to examine if any demographic and clinical characteristics were associated with lower HRQoL scores and shorter distances at the 6MWDT. RESULTS: Domains presenting lower HRQoL scores were vitality (64.0 ± 17.3), mental health (67.3 ± 8.0), role emotional (69.7 ± 35.8) in the SF-36 questionnaire; general health perceptions (61.3 ± 8.3), general behavior (61.9 ± 15.6), parental impact-emotional (67.7 ± 28.7) in the CHQ-PF50. Female gender (P = 0.009), left ventricular ejection fraction lower than 55% (P = 0.013), cardiovascular drugs (P = 0.003) were significantly associated with lower HRQoL scores. Average distance traveled during the 6MWDT was 539.8 ± 82.9 m. The 6MWDT showed significant association with age (P = 0.006) and cardiovascular drugs (P = 0.024). CONCLUSIONS: Chronic RV pacing did not affect the HRQoL and physical capacity of pediatrics and young subjects. Female gender, ventricular function, and cardiovascular drugs were associated with lower HRQoL scores. Older subjects walked shorter distances in the 6MWDT, as well as subjects who were taking cardiovascular drugs.
No takes yet. Share an insight, caveat, or question.
Silva et al. (2013) conducted an observational in Congenital complete atrioventricular block (CCAVB) (n=66). Chronic right ventricular (RV) pacing was evaluated on Health-related quality of life (HRQoL) and functional exercise capacity. Chronic right ventricular pacing in subjects with congenital complete AV block yielded an average 6-minute walk distance of 539.8 m, with female gender associated with lower HRQoL (P=0.009).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: